Hyeun Joong Yoon

Contact

hjyoon@mtu.edu
906-487-1129
M&M 306

Assistant Teaching Professor, Biomedical Engineering

PhD, Electrical Engineering, Ajou University, Korea
MS, Electrical Engineering, Ajou University, Korea
BS, Mechanical Engineering, Electrical Engineering, Ajou University, Korea

Biography

Hyeun Joong Yoon received his BS, MS, and PhD degrees in Electrical Engineering from Ajou University, Korea. He was a postdoctoral research fellow in the Department of Chemical Engineering at the University of Michigan between 2010 to 2015. Prior to joining Michigan Tech, he was an assistant professor at the University of Nevada Reno and South Dakota State University.

Dr. Yoon’s current research is to develop advanced bioMEMS tools for understanding cell trafficking in cancer through isolation, characterization, and study of circulating tumor cells in the peripheral blood of cancer patients.

His goal is to create cutting edge engineering solutions to clinical problems with novel translational biomedical research tools. He has published more than 20 journal papers including Nature Nanotechnology, Advanced Materials, ACS Nano, Sensors and Actuators A, B, etc.

Links of Interest

Hyeun Joong Yoon in Google Scholar

Teaching Experience

Tissue Engineering
Biomicrofluidics for Regenerative Medicine
Biomedical Instrumentation
Biomedical Device and Biosensors
Electrical Properties of Materials
Basic Electrical Engineering

Research Interests

Circulating tumor cells
Tumor microenvironment
Rare cell isolation and single-cell analysis
Microfluidics, BioMEMS devices, Biosensors

Recent Publications

1. Tae Hyun Kim^*, Hyeun Joong Yoon^*, Shamileh Fouladdel, Yang Wang, Molly Kozminsky, Monika L. Burness, Costanza Paoletti, Lili Zhao, Ebrahim Azizi, Max S. Wicha, and Sunitha Nagrath, “Characterizing Circulating Tumor Cells Isolated from Metastatic Breast Cancer Patients using Graphene Oxide based Microfluidic Assay,” Advanced Biosystems, Vol. 3(2), 18800278, 2019. (Co-first author)

2. Kyung Eun You, Nezam Uddin, Tae Hyun Kim, Qi Hua Fan, and Hyeun Joong Yoon^*, “Highly Sensitive Detection of Biological Substances using Microfluidic Enhanced Fabry-Perot Etalon-Based Optical Biosensors,” Sensors and Actuators B, Vol. 277, pp. 62-68, 2018.

3. Eric Lin, Lianette Rivera-Baez, Shamileh Fouladdel, Hyeun Joong Yoon, Stephanie Guthrie, Jacob Wieger, Yadwinder S. Deol, Evan Keller, Vaibhav Sahai, Diane M. Simeone, Monika L. Burness, Ebrahim Azizi, Max S. Wicha and Sunitha Nagrath, “High Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells,” Cell Systems, Vol. 5(3), pp. 295-304.e4, 2017.

4. Nezam Uddin, Maheshwar Shreshtha, Bocong Zheng, Hyeun Joong Yoon, Xiuqing Wang, and Qi Hua Fan, “Liquid Sensors based on Enhanced Fabry-Perot Etalons,” IEEE Sensors Journal, Vol. 17(22), pp. 7348-7354, 2017.

5. Hyeun Joong Yoon, Apoorv Shanker, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika L. Burness, Ebrahim Azizi, Diane M. Simeone, Max S. Wicha, Jinsang Kim, and Sunitha Nagrath, “Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells,” Advanced Materials, Vol. 28, pp. 4891-4897, 2016.

6. Yusuke Shiozawa, Janice E. Berry, Matthew R. Eber, Younghun Jung, Kenji Yumoto, Frank C. Cackowski, Hyeun Joong Yoon, Princy Parsana, Rohit Mehra, Jingcheng Wang, Samantha McGee, Eunsohl Lee, Sunitha Nagrath, Kenneth J. Pienta, and Russell S. Taichman, “The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer,” Oncotarget, Vol. 7, No. 27, pp. 41217-41232, 2016.

7. Woong Hee Lee, Thitaphat Ngernsutivorakul, Omar S. Mabrouk, Jenny-Marie T. Wong, Colleen E. Dugan, Samuel S. Pappas, Hyeun Joong Yoon, and Robert T. Kennedy, “Microfabrication and in Vivo Performance of a Microdialysis Probe with Embedded Membrane,” Analytical Chemistry, Vol. 88(2), pp. 1230-1237, 2016.

8. Hyeun Joong Yoon, Molly Kozminsky and Sunitha Nagrath, “Emerging Role of Nanomaterials in Circulating Tumor Cells Research,” ACS Nano, Vol. 8, pp. 1995-2017, 2014.

9. Tae Hyun Kim, Hyeun Joong Yoon, Philip Stella and Sunitha Nagrath, “Cascaded Spiral Microfluidic Device for Deterministic and High Purity Continuous Separation of Circulating Tumor Cells,” Biomicrofluidics, 8 (6), 064117, 2014.

10. Hyeun Joong Yoon, Tae Hyun Kim, Zhuo Zhang, Ebrahim Azizi, Trinh M. Pham, Costanza Paoletti, Jules Lin, Nithya Ramnath, Max S. Wicha, Daniel F. Hayes, Diane M. Simeone and Sunitha Nagrath, “Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets,” Nature Nanotechnology, Vol. 8, pp. 735-741, 2013. - This paper was ranked 1^st in the Top 10 most read papers from Nature Nanotechnology in October. Highlighted by Nature Reviews Clinical Oncology, Science Translational Medicine, Nano Today, UM News Service, UM Engineering News, Medical News Today, Science Daily, The Medical News, Science Newsline, Health Canal, Phys.org, Nanowerk, EurekAlert!, e! Science News.

11. Hyeun Joong Yoon, Do Han Jun, Jin Ho Yang, Zhixian Zhou, Sang Sik Yang and Mark Ming-Cheng Cheng, “Carbon dioxide gas sensor using a graphene sheet,” Sensors and Actuators B, Vol. 157, pp. 310-313, 2011. - Most Cited Articles in Sensors and Actuators B: Chemical

Presentations

1. John Lee, Kyung Eun You, Hyeun Joong Yoon^*, “Particle Separation Using a Microfluidic Device for Circulating Tumor Cell Isolation,” 2019 BMES Annual Meeting, Philadelphia, Pennsylvania, USA, October 16-19, 2019.

2. Braden Norris, Kyung Eun You, John Lee, Derrick Hau, Erin L. Benson, Emily E. Sewell, David P. AuCoin, Hyeun Joong Yoon^*, “Label Free Colorimetric Bacterial Detection with Polydiacetylene Liposomes,” 2019 BMES Annual Meeting, Philadelphia, Pennsylvania, USA, October 16-19, 2019.

3. Richard Wang, Kyung Eun You, Hyeun Joong Yoon^*, “Graphene Oxide Functionalized Biosensor for Detection of Stree-Related Biomarkers,” 2019 BMES Annual Meeting, Philadelphia, Pennsylvania, USA, October 16-19, 2019.

4. Kyung Eun You, Seung Mi Kim, and Hyeun Joong Yoon^*, “GO-based Paper Sensor for Point of Care Detection of Stress-related Markers,” 2018 BMES Annual Meeting, Atlanta, Georgia, USA, October 17-20, 2018.

5. Hyeun Joong Yoon^*, Kyung Eun You, “Recent Microfluidic Technologies for Study of Circulating Tumor Cells,” 6^th Nano Today Conference, Lisbon, Portugal, June 16-20, 2019.

6. Kyung Eun You, Shailu Shree Poudyal, Seung Mi Kim, and Hyeun Joong Yoon^*, “Detection of Stress-related Markers from Sweat with Wearable Biosensor,” 2018 Materials Research Society (MRS) Spring Meeting & Exhibit, Phoenix, Arizona, USA, April 2-6, 2018. (Won Best Poster Award)

7. Kyung Eun You, Shailu Shree Poudyal, Kaitlin A.T. Wickre, Lei Zhao, Michael Henry, Mohammed Milhem, and Hyeun Joong Yoon^*, “Early Diagnosis of Melanoma with Isolation and Detection of Circulating Melanoma Cells using a Microfluidic Device,” 5^th Nano Today Conference, Hawaii, USA, December 6-10, 2017. (Won Student Travel Award)

8. Kyung Eun You, Shailu Shree Poudyal, Kaitlin A.T. Wickre, Lei Zhao, Michael Henry, Mohammed Milhem, and Hyeun Joong Yoon^*, “Gold Nanoparticle Based Microfluidic Device for Highly Efficient Isolation of Circulating Melanoma Cells,” 2017 BMES Annual Meeting, Phoenix, Arizona, USA, October 11-14, 2017.

9. Shailu Shree Poudyal, Kyung Eun You, and Hyeun Joong Yoon^*, “Graphene Oxide-Based Microfluidic Cortisol Sensor with Enhanced Sensitivity,” 2017 BMES Annual Meeting, Phoenix, Arizona, USA, October 11-14, 2017

10. Qiwei Wang, Ji Young Lee, Teddrick Schaffer, Sung Y. Shin, and Hyeun Joong Yoon^*, “Integration of Flexible Wearable Sensors with Wireless Communication Systems for Health Monitoring,” 2016 BMES Annual Meeting, Minneapolis, Minnesota, USA, October 5-8, 2016.

11. Christopher Rumrill, Qiwei Wang, and Hyeun Joong Yoon^*, “Flexible Biosensor to Monitor Ion Concentrations via Sweat Analysis,” 2016 BMES Annual Meeting, Minneapolis, Minnesota, USA, October 5-8, 2016.

12. Tae Hyun Kim, Hyeun Joong Yoon, and Sunitha Nagrath, “Identification and characterization of EMT/MET signatures in circulating tumor cells isolated from patients with metastatic breast cancer using graphene oxide nano-chip,” American Association for Cancer Research (AACR) Annual Meeting 2016, New Orleans, Louisiana, USA, April 16-20, 2016.

13. Eric Lin, Lianette Rivera, Shamileh Fouladdel, Hyeun Joong Yoon, Stephanie Guthrie, Jacob Weiner, Yadwinder S. Deol, Evan Keller, Vaibhav Sahai, Diane M. Simeone, Monika L. Burness, Ebrahim Azizi, Max S. Wicha, and Sunitha Nagrath, “Label-free high throughput microfluidic device for the isolation and single cell multiplex gene expression analysis of circulating tumor cells from breast cancer patients,” American Association for Cancer Research (AACR) Annual Meeting 2016, New Orleans, Louisiana, USA, April 16-20, 2016.

14. Apoorv Shanker, Hyeun Joong Yoon, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika Burness, Ebrahim Azizi, Diane Simeone, Max S. Wicha, Jinsang Kim, and Sunitha Nagrath, “Microfluidic Device Based on Tunable Thermo-Responsive Polymer-Graphene Oxide (GO) Composite Film for Efficient CTC Isolation and Enumeration,” 2015 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts, USA, Nov. 29-Dec. 4, 2015.

15. Tae Hyun Kim, Hyeun Joong Yoon, Molly Kozminsky, Courtney Riley, and Sunitha Nagrath, “Dielectrophoretic attraction and isolation of circulating tumor cells using graphene oxide functionalized gold electrodes,” 2015 BMES Annual Meeting, Tampa, Florida, USA, October 7-10, 2015.

16. Yang Wang, Hyeun Joong Yoon, Meredith A. Morgan, Shamileh Fouladdel, Ebrahim Azizi, Max Wicha, Kyle Cuneo, Diane Simeone, and Sunitha Nagrath, “Isolation and characterization of pancreatic cancer circulating tumor cells by graphene oxide based microfluidic device (GO Chip),” 2015 BMES Annual Meeting, Tampa, Florida, USA, October 7-10, 2015.

17. Hyeun Joong Yoon, Apoorv Shanker, Yang Wang, Molly Kozminsky, Shamileh Fouladdel, Monika L. Burness, Ebrahim Azizi, Max S. Wicha, Jinsang Kim, and Sunitha Nagrath, “Capture and Release of Circulating Tumor Cells by Temperature-Sensitive Graphene Oxide-Polymer Composite,” American Association for Cancer Research (AACR) Annual Meeting 2015, Philadelphia, Pennsylvania, USA, April 18-22, 2015.

18. Molly Kozminsky, Hyeun Joong Yoon, Nallasivam Palanisamy, Kathleen Cooney, Maha Hussain, Ajjai Alva, Todd Morgan, and Sunitha Nagrath, “Application of a graphene oxide based microfluidic device (GO Chip) to prostate cancer circulating tumor cell capture and analysis,” American Association for Cancer Research (AACR) Annual Meeting 2015, Philadelphia, Pennsylvania, USA, April 18-22, 2015.

19. Lianette Rivera-Baez, Eric Lin, Hyeun Joong Yoon, Meghna Waghray, Shamileh Fouladdel, Ebrahim Azizi, Max Wicha, Diane Simeone, and Sunitha Nagrath, “Application of label-free microfluidic technologies for the enrichment, expansion and characterization of circulating tumor cells in pancreatic cancer,” American Association for Cancer Research (AACR) Annual Meeting 2015, Philadelphia, Pennsylvania, USA, April 18-22, 2015.

20. Eric Lin, Lianette Rivera-Baez, Hyeun Joong Yoon, Shamileh Fouladdel, Stephanie Guthrie, Jacob Wieger, Yadwinder S. Deol, Tahra K. Luther, Shawn G. Clouthier, Diane M. Simeone, Monika L. Burness, Ebrahim Azizi, Max S. Wicha, and Sunitha Nagrath, “Label-free high throughput microfluidic device for the isolation of circulating tumor cells from breast cancer patients,” American Association for Cancer Research (AACR) Annual Meeting 2015, Philadelphia, Pennsylvania, USA, April 18-22, 2015.

21. Shamileh Fouladdel, Hyeun Joong Yoon, Eric Lin, Tae Hyun Kim, Yadwinder S. Deol, Tahra Luther, Shawn G. Clouthier, Monika L. Burness, Sunitha Nagrath, Ebrahim Azizi, and Max S. Wicha, “Gene expression signatures of isolated circulating tumor cells from metastatic breast cancer patients reveal presence of breast cancer stem cells with EMT or MET phenotypes,” American Association for Cancer Research (AACR) Annual Meeting 2015, Philadelphia, Pennsylvania, USA, April 18-22, 2015.

22. Tae Hyun Kim, Hyuen Joong Yoon, and Sunitha Nagrath, “Optimization approach for inertial focusing and separation of cells in spiral microchannels,” The 18^th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), San Antonio, TX, USA, October 26-30, 2014.

23. Angela Yang Wang, Hyeun Joong Yoon, Jesisky Tandy, Ebrahim Azizi, Max Wicha, and Sunitha Nagrath, “Investigation of the survival of circulating breast tumor cells using biomimetic microfluidic circulating system,” American Association for Cancer Research (AACR) Annual Meeting 2014, San Diego, CA, USA, April 5-9, 2014.

24. Shamileh Fouladdel, Hyeun Joong Yoon, Tae Hyun Kim, An Shi, Tahra Luther, Jill Hayden, Shawn Clouthier, Yadwinder Deol, Monika Burness, Dan Hayes, Sunitha Nagrath, Ebrahim Azizi, and Max Wicha, “Circulating tumor cells (CTCs) isolated from patients with metastatic breast cancer utilizing a sensitive microfluidic graphene oxide (GO) nanosheet device express markers of cancer stem cells,” American Association for Cancer Research (AACR) Annual Meeting 2014, San Diego, CA, USA, April 5-9, 2014.

25. Hyeun Joong Yoon, Tae Hyun Kim, Zhuo Zhang, Azizi Ebrahim, Costanza Paoletti, Jules Lin, Nithya Ramnath, Max S. Wicha, Daniel F. Hayes, Diane M Simeone, and Sunitha Nagrath, “Integrated micro nanotechnology for sensitive detection of cancer cells in circulation,” 2013 AIChE Annual Meeting, San Francisco, CA, USA, November 3-8, 2013.

26. Hyeun Joong Yoon, Tae Hyun Kim, Zhuo Zhang, Nithya Ramnath, Max S. Wicha, Daniel F. Hayes, Diane M Simeone, and Sunitha Nagrath, “Integrated micro nanotechnology for the sensitive isolation of circulating tumor cells,” American Association for Cancer Research (AACR) Annual Meeting 2013, Washington, DC, USA, April 6-10, 2013.

27. Hyeun Joong Yoon, Tae Hyun Kim, Zhuo Zhang, Trinh M. Pham, and Sunitha Nagrath, “Isolation and capture of circulating tumor cells by a microfluidic device with functionalized planar structures,” 2012 AIChE Annual Meeting, Pittsburgh, PA, USA, October 28-November 2, 2012.

28. Eric Lin, Hyeun Joong Yoon, Yang Wang, Trinh M. Pham, and Sunitha Nagrath, “High throughput cell separation device for the enrichment of circulating tumor cells,” 2012 AIChE Annual Meeting, Pittsburgh, PA, USA, October 28-November 2, 2012.

29. Tae Hyun Kim, Hyeun Joong Yoon, Eric Lin, Saarika Ketkar, and Sunitha Nagrath, “A continuous label-free cell separation device combining inertial microfluidics and dielectrophoresis,” 2012 AIChE Annual Meeting, Pittsburgh, PA, USA, October 28-November 2, 2012.

30. Hyeun Joong Yoon, Trinh M Pham, Kilho Lee and Sunitha Nagrath, “Sensitive detection of circulating tumor cells by graphene oxide nanoassembly,” 2011 AIChE Annual Meeting, Minneapolis, Minnesota, USA, Oct. 16-21, 2011.

31. Hyeun Joong Yoon, Kilho Lee, Zhuo Zhang, Trinh M. Pham and Sunitha Nagrath, “Nanoassembly of graphene oxide for circulating tumor cell isolation,” The 15^th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), Seattle, USA, October 2-6, 2011.

32. Hyeun Joong Yoon, Yiyang Zhang, Seung Soo Kim, Zhixian Zhou and Mark Ming-Cheng Cheng, “A flexible biocompatible graphene sensor for real-time monitoring of pH and protein binding,” The 6^th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS), Kaohsiung, Taiwan, Feb 20-23, 2011.

33. Xuebin Tan, Hyuen Joong Yoon, James G. Granneman, Hsiao-Ping Moore and Mark Ming-Cheng Cheng, “A high-throughput microfluidic chip for size sorting of cells,” The 24^th International Conference on Micro Electro Mechanical Systems (IEEE MEMS), Cancun, Mexico, Jan 23-27, 2011.

34. Hyeun Joong Yoon, Seung Soo Kim, Lijie Ci, Li Song, Pulickel M. Ajayan, Zhixian Zhou and Mark Ming-Cheng Cheng, “Biosensor array using CVD graphene,” Graphene Week 2010, College Park, Maryland, USA, April 19-23, 2010.

35. H. J. Yoon, J. H. Yang, S. S. Yang and E. H. Yang, “Microfabricated nanowire diluter for controlled assembly of nanowires,” ASME International Mechanical Engineering Congress & Exposition, Boston, U.S.A., October 31-November 6, 2008.

36. H. J. Yoon, S. H. Song, J. B. Cho, K. W. Jung, S. Lee, K. H. Koh and S. S. Yang, “Fabrication of an ion source using carbon nanoparticle field emitters for a micro time-of-flight mass spectrometer,” The 14^th International Conference of Solid-State Sensors, Transducers’07, Lyon, France, June 10-14, 2007.

37. J. B. Cho, H. J. Yoon, K. W. Jung, S. S. Yang, K. H. Koh and S. Lee, “Micro mass spectrometer using triode electron emitters with a planar carbon-nanoparticle cathode as ion source,” 2^nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Bangkok, Thailand, January 16-19, 2007.

38. K. P. Hong, H. J. Yoon, et al, “Development of high image quality and low power consumption TFT-LCD with Data Rendering Innovation Matrix(DRIM),” IMID’05 Digest, Seoul, Korea, pp. 368-370, 2005.

39. H. J. Yoon, et al, “Development of the RGBW TFT-LCD with Data Rendering Innovation Matrix,” SID’05 Symposium Digest, Boston, U.S.A., Vol. 35, pp. 244-247, May 23-27, 2005.

40. J. S. Jeong, H. J. Yoon and S. S. Yang, “A Novel Pressure Telemetry via RF Power Transmission,” The 17th European Conference of Solid-State Transducers, Eurosensors XVII, Guimaraes, Portugal, Sep. 21-24, 2003.

41. S. W. Lee, H. J. Yoon and S. S. Yang, “Fabrication of a Two-way Pressure Regulation Micro Valve with the Anti-siphon Effect,” Proc. MEMS, ASME Int. Mechanical Engineering Congress and Exposition, New Orleans, U.S.A., Nov. 17-22, 2002.

42. H. J. Yoon, S. W. Lee, H. J. Kim and S. S. Yang, “Development of a Novel Cerebrospinal Fluid (CSF) Shunt System,” The 16th European Conference of Solid-State Transducers, Eurosensors XVI, Prague, Czech Republic, pp. 421-424, Sep. 15-18, 2002.

43. H. J. Yoon, W. Y. Sim and S. S. Yang, “The Fabrication and Test of a Phase-change Micropump,” Proc. MEMS, ASME Int. Mechanical Engineering Congress and Exposition, New York, U.S.A., MEMS-23870, Nov. 11-16, 2001.

44. H. J. Yoon, J. H. Kim, T. G. Park, S. S. Yang and K. W. Jung, “The Fabrication of the Novel Micro Time-of-Flight (TOF) Mass Spectrometer with a Micro Ion Source,” The 11th International Conference on Solid-State Sensors and Actuators, Transducers '01 and Eurosensors XV, Munich, Germany, pp. 394-397, June 10-14, 2001.

45. H. J. Yoon, J. H. Kim, T. G. Park, S. S. Yang and K. W. Jung, “The Test of Hot Electron Emission for the Micro Mass Spectrometer,” Design, Test, Integration and Packaging of MEMS/MOEMS 2001, Cote d’Azur, France, SPIE Vol. 4408, pp. 360-367, April 25-27, 2001.

46. H. J. Yoon, S. Y. Kim, S. W. Lee and S. S. Yang, “Fabrication of a Micro Electromagnetic Flow Sensor for Micro Flow Rate Measurement,” Proc. of SPIE’s 7^th International Symposium on Smart Structures and Materials, California, USA, SPIE Vol. 3990, pp. 264-271, March 6-8, 2000.