The biofluids lab utilizes fluid and solid mechanics principles, clinical expertise and design and manufacturing to find solutions for cardiovascular flow problems. The lab scope involves both basic and translational studies. The lab utilizes a custom-designed and built pulse duplicator system that emulates that of the cardiovascular system. In this flow simulator setup, hemodynamic assessment of adult and congenital heart defects can take place.
Special equipment used in the lab involves a particle image velocimetry system that allows the characterization of the flow field in vessels and organs.
Location: Minerals and Materials 312
Contact: Hoda Hatoum
Biomedical Microdevices Lab
Micro- and nano- structures have a significant contribution in the physical world in spite of their seemingly insignificant dimensions. The Biomedical µDevices lab focuses on investigating these microscopic structures that affect physiology and cell biology. The multidisciplinary research extends to understanding and manipulating the microenvironment to study A) cancer metastasis and B) wound healing.
Location: Minerals and Materials 330, 330A
Contact: Smitha Rao
Biomedical Optics Laboratory
Research in the Biomedical Optics Laboratory is concerned with the way light interacts with human tissue and how this interaction can be used for developing novel ways to image physiological processes and anatomical structures, for developing new laser-based optical diagnostic tools, and even for developing new ways to use light in the treatment of disease. The lab is a fully equipped, modern optics facility that houses vibration-isolated optical benches, numerous types of lasers and other light sources, state-of-the-art optoelectronic equipment, optical components, computers for conducting numerical simulations and for collecting and analyzing data, and an area for preparing and studying biological tissues and samples.
Location: Minerals and Materials 114/115
Contact: Sean Kirkpatrick
Engineered Biomaterials Laboratory
Laboratory activities include biomaterials synthesis and characterization, histological processing, and molecular biological analysis. Studies focus on characterizing native and pathological tissue behavior to develop rationale designs for new biomaterials that regulate cell and tissue regeneration and repair. Areas of expertise include biomimetic materials, cell and tissue mechanics, and the host response to implantable materials.
Location: Minerals and Materials 330/331
Contact: Rupak Rajachar
Bruce Lee Research Group
The Lee group research is focused on applying biologically-inspired molecular designs with chemistry, polymer engineering and materials science principles in developing advanced and functional materials for various biomedical applications. Current projects include applying biomimetic structural designs to create tough hydrogels that can potentially function as tissue adhesives or extracellular matrices for tissue repair and regeneration, and hydrogel actuators and smart adhesives.
Contact: Bruce Lee
We study mechanobiology, particularly on how adherent cells can sense and respond to mechanical stiffness of the extracellular matrix. To investigate this, we have established experimental and computational frameworks for force measurement and adhesion dynamics quantification. We apply these frameworks, with cutting edge computer vision technique, on live-cell microscope images to find out fundamental mechanism underlying mechanosensation in the normal cells and the biomechanical signature in the diseased cells whose signaling has gone awry.
Contact: Sangyoon Han
The microdevices lab is a multi-disciplinary lab bringing together the diverse aspects of biomedical engineering. On-going research encompasses electrical engineering, mechanical engineering, tissue engineering and polymer chemistry. The lab is equipped with enclosed climate controlled electrospinning equipment for scaffold and sensing applications, mechano-culture chamber to study mechanical stresses on cells, fluorescent and brightfield imaging with an on-board incubation chamber for long-term imaging, fully functional tissue culture facility with biosafety cabinet (BSL-2), incubator (dual gas flow controlled), brightfield microscope (primovert), function generators, oscilloscopes, soldering station, pH measurement system, TEER measurement system, home-built contact angle measurement set-up, hand-held corona treater, multi-mode plate reader. The lab also has capability for carrying out standard chemical processing.
Location: Minerals and Materials 330
Contact: Smitha Rao
Polymeric Biomaterials Laboratory
Laboratory activities include research involving implanted polymer development, implantable sensor development, effects of nitric oxide on cells and tissues, biocompatibility, and biomaterials interfaces. Specialized equipment used in the lab includes a nitric oxide analyzer (chemiluminescence detection), fiber-optic UV-visible and fluorescence spectrometers, and a UV-visible dual-beam spectrometer.
Location: Minerals and Materials 337
Contact: Megan Frost
Tissue Engineering and Biomaterials Facility
The facility’s activities include mammalian cell culture; tissue culture; bioreactor design and operation; biomaterial fabrication; and polymer synthesis.
Location: Minerals and Materials 414
Contacts: Feng Zhao and Bruce P. Lee
Vascular Engineering Laboratory
Laboratory activities are focused on understanding how reduced interstitial flow, following lymphatic injuries, alters lymphatic regeneration and recovery of lymphatic function. The long-term goal of this research is to develop novel biomaterial and tissue engineering strategies for increasing interstitial flow, thereby improving lymphatic regeneration.
The lab is equipped for small-animal surgeries, tissue cryosectioning, fluorescence and brightfield microscopy, and live lymphatic imaging. Specialized instruments include an Olympus BX51 microscope and a Zeiss Apotome fluorescence microscope, both equipped with a high-resolution color digital camera; two Olympus stereo microscopes, available for small-animal surgeries with affixed DP71 digital color cameras; and a Near Infrared (NIR) imaging system, available for live imaging of lymphatic vessels in both rodents and humans.
Location: Minerals and Materials 332
Contact: Jeremy Goldman