Yan Zhang

Yan Zhang


  • Research Assistant Professor, Biological Sciences
  • PhD, Pharmacology and Toxicology, University of Missouri-Kansas City
  • MS, Pharmacology, Peking Union Medical College
  • BS, Pharmacy, Sichuan Univeristy


Autosomal dominant polycystic kidney disease (ADPKD) is the most common, potentially lethal genetic disorder characterized by the progressive enlargement of numerous fluid-filled cysts and the development of interstitial inflammation and fibrosis. ADPKD is caused by the mutation of PKD1 or PKD2 gene. Approximately 50% of patients progress to end-stage renal disease by middle age and require dialysis or renal transplantation. Currently, treatment options for ADPKD patients are limited; thus, the development of new effective therapies is urgent. Dr. Zhang’s research lab investigates the role of innate immunity in the pathological microenvironment of ADPKD and the potential therapeutic effects of manipulating innate immunity. Dr. Zhang's lab is also interested in determining the function of polycystin-1 encoded by PKD1. 

Links of Interest

Google Scholar Profile

Positions Available

  • Ph.D. Research Assistantship
    • Previous experiences in molecular biology, cell biology, and animal studies are preferred
    • Send CV to yzhang49@mtu.edu