Tarun K. Dam
- Chem Sci 510C
- Professor, Chemistry
- Director, Biochemistry and Molecular Biology (BMB) Program
- PhD, University of Calcutta, India
- Postdoctoral, Albert Einstein College of Medicine, New York
- Faculty, Albert Einstein College of Medicine, New York
Tarun Dam started his research in the area of Glycobiology as a graduate student of Professor Amalesh Choudhury. He was trained in the laboratories of Dr. Manju Sarkar (Indian Institute of Chemical Biology, Kolkata) and Professor Avadhesha Surolia (Indian Institute of Science, Bangalore). Dr. Dam joined the Albert Einstein College of Medicine, New York, as a postdoctoral fellow to work with Professor C. Fred Brewer, where he focused on molecular and structural Glycobiology. Dr. Dam joined the faculty of the Albert Einstein College of Medicine after completing his postdoctoral training. Subsequently, he joined the Chemistry Department of Michigan Technological University, where he is now a Professor and the Director of the Biochemistry and Molecular Biology Graduate program. Dr. Dam received several awards including Young Scientist Award, Bhakta Rath Research Award, Distinguished Teaching Award, and Exceptional Mentor Award. Research work in his lab, (the Laboratory of Mechanistic Glycobiology) is focused on (i) the multi-functional and cancer-associated human protein galectin-3, (ii) novel bioactive natural products from plants, and (iii) formulation and validation of new detection/purification methods.
Links of Interest
- Molecular basis of glycan (carbohydrate)-mediated biological functions
- Glycan binding proteins or lectins
- Glycan detection
- Mechanistic glycobiology
- Macromolecular communication
- Biomolecular thermodynamics
- Edwards, J. L., Kadav, P. D., Bandyopadhyay, P., Dam T. K. Revealing the identity of human Galectin-3 as a glycosaminoglycan-binding protein. Methods in Molecular Biology, in press. (2021).
- Kadav, P. D., Edwards, J. L., Krycia, J., Bandyopadhyay, P., Dam T. K. Rapid detection and purification of Galectin-3 by the Capture and Release (CaRe) method. Methods in Molecular Biology, in press. (2021).
- Dam T. K., Edwards, J. L., Kadav, P. D., Brewer, C. F. Mechanism of Mucin Recognition by lectins – A thermodynamic study. Methods in Molecular Biology, in press. (2021).
- Kadav, PD , Edwards, J.L., Bandyopadhyay, P., Brewer, C F, Dam, TK. Molecular and Mechanistic Basis of Lectin-Glycan Interactions. Comprehensive Glycoscience (Second Edition), Volume 3, 2021, Pages 346-404. https://www.sciencedirect.com/science/article/pii/B9780128194751000547#!
- Welch CJ, Kadav PD, Edwards JL, Krycia J, Talaga ML, Bandyopadhyay P, Dam TK. A Rapid and Facile Purification Method for Glycan-Binding Proteins and Glycoproteins. Curr Protoc Protein Sci. 2020 Sep;101(1):e113. doi: 10.1002/cpps.113. PMID: 32882112.
- Welch CJ, Talaga ML, Kadav PD, Edwards JL, Bandyopadhyay P, Dam TK. A capture and release method based on noncovalent ligand cross-linking and facile filtration for purification of lectins and glycoproteins. J Biol Chem. 2020 Jan 3;295(1):223-236. doi: 10.1074/jbc.RA119.010625. Epub 2019 Dec 2. PMID: 31792056; PMCID: PMC6952606.
- Talaga ML, Fan N, Fueri AL, Brown RK, Bandyopadhyay P, Dam TK. Multitasking Human Lectin Galectin-3 Interacts with Sulfated Glycosaminoglycans and Chondroitin Sulfate Proteoglycans. Biochemistry, 55, 4541-51, (2016).
- Dam TK, Talaga ML, Fan N, Brewer CF. Measuring Multivalent Binding Interactions by Isothermal Titration Calorimetry. Methods Enzymol., 567, 71-95, (2016).
- Fan N, Talaga ML, Brown RK, Fueri AL, Bandyopadhyay P, Dam TK. Glycan-Dependent Mutual and Reversible Sequestration of Two Thyroid Cancer Biomarkers. Thyroid, 25, 1339-46, (2015).
- Talaga ML, Fan N, Fueri AL, Brown RK, Chabre YM, Bandyopadhyay P, Roy R, Dam TK. Significant other half of a glycoconjugate: contributions of scaffolds to lectin-glycoconjugate interactions. Biochemistry. 2014 Jul 15;53(27):4445-54. doi: 10.1021/bi5001307. Epub 2014 Jul 3.