Summary of recommended biosafety levels for management of biological organisms. The laboratory director is specifically and primarily responsible for assessing the risks and applying the appropriate biosafety levels. The Institutional Biosafety Committee (IBC) can be of great assistance in performing and reviewing the required risk assessment.
|Source: Biosafety in Microbiological and Biomedical Laboratories (BMBL).|
|Biosafety Level (BSL)||Controls||Corresponding Risk Group/Representative Organisms|
||Risk Group 1 agents are not associated with disease in healthy adults. Examples include: E. coli K-12, Laccaria bicolor, Saccharomyces cerevisiae, Lactobacillus acidophilus, Baculoviruses, adeno-associated virus.|
||Risk Group 2 agents are associated with human or animal diseases that are rarely serious. Effective treatment and preventative measures are available. Examples include: working with human blood, Streptococcus pyogenes, Giardia spp., Microsporum canis, human adenoviruses, Hepatitis virus.|
||Risk Group 3 agents are associated with serious or lethal human or animal diseases. Effective treatment and preventive measures may be available. Examples include: Yersinia pestis, Francisella tularensis, Coccidioides immitis, Prions, Hantavirus, and Influenza viruses A H1N1 (1918), H2N2 (57-68), and H5N1 (bird flu).|
||Risk Group 4 agents cause serious or lethal human or animal disease and are readily transmitted. Effective treatment and preventive measures are not usually available. Examples include: Smallpox virus, Ebola virus. No bacteria, fungi, or parasites in this group.|