Lanrong Bi

Contact

lanrong@mtu.edu
906-487-1868
Chem Sci 620A

Associate Professor, Chemistry
Affiliated Associate Professor, Biological Sciences

Associate Research Scientist, Columbia Genome Center, College of Physicians and Surgeons, Columbia University
Postdoctoral Research Scientist, Columbia Genome Center/Department of Chemical Engineering, Columbia University
Postdoctoral Research Scientist, Columbia Genome Center/Department of Chemical Engineering, Columbia University

Research Interests

Chemical biology: development of novel molecular probes for DNA sequencing analysis and disease gene discovery
Medicinal chemistry: development of new imaging and therapeutic agents towards cancer and cardiovascular disease; Design and synthesis of novel prodrugs of peptides and peptide mimetics.

Recent Publications

Novel TEMPO-PEG-RGDs Conjugates Remediate Tissue Damage Induced by Acute Limb Ischemia/Reperfusion. Bi W, Li X, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Itagaki Y, Bi L. J. Med. Chem. 2012 May 10;55(9):4501-5.
Determination of intracellular pH using sensitive, clickable fluorescent probes. Yapici NB, Mandalapu SR, Chew TL, Khuon S, Bi L. Bioorg Med Chem Lett. 2012 Apr 1; 22(7):2440-3.
New rhodamine nitroxide based fluorescent probes for intracellular hydroxyl radical identification in living cells. Yapici NB, Jockusch S, Moscatelli A, Mandalapu SR, Itagaki Y, Bates DK, Wiseman S, Gibson KM, Turro NJ, Bi L. Org Lett. 2012 Jan 6;14(1):50-3.
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Li X, Gibson KM, Bi L. Eur J Med Chem. 2011 Jun;46(6):2441-52.
A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM, Bi L. Eur J. Med Chem. 2011 May;46(5):1453-62.
Synthetic oligodeoxynucleotide purification by polymerization of failure sequences. Fang S, Fueangfung S, Lin X, Zhang X, Mai W, Bi L, Green SA. Chem Commun (Camb). 2011 Jan 28;47(4):1345-7.
Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM, Bi L. J. Med Chem. 2010 Sep 23;53(18):6763-7.

Publications

Novel TEMPO-PEG-RGDs Conjugates Remediate Tissue Damage Induced by Acute Limb Ischemia/Reperfusion. Bi W, Li X, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Itagaki Y, Bi L. J. Med. Chem. 2012 May 10;55(9):4501-5.
Determination of intracellular pH using sensitive, clickable fluorescent probes. Yapici NB, Mandalapu SR, Chew TL, Khuon S, Bi L. Bioorg Med Chem Lett. 2012 Apr 1; 22(7):2440-3.
New rhodamine nitroxide based fluorescent probes for intracellular hydroxyl radical identification in living cells. Yapici NB, Jockusch S, Moscatelli A, Mandalapu SR, Itagaki Y, Bates DK, Wiseman S, Gibson KM, Turro NJ, Bi L. Org Lett. 2012 Jan 6;14(1):50-3.
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Li X, Gibson KM, Bi L. Eur J Med Chem. 2011 Jun;46(6):2441-52.
A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM, Bi L. Eur J. Med Chem. 2011 May;46(5):1453-62.
Synthetic oligodeoxynucleotide purification by polymerization of failure sequences. Fang S, Fueangfung S, Lin X, Zhang X, Mai W, Bi L, Green SA. Chem Commun (Camb). 2011 Jan 28;47(4):1345-7.
Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM, Bi L. J. Med Chem. 2010 Sep 23;53(18):6763-7.
Renal ischemia/reperfusion injury in rats is attenuated by a synthetic glycine derivative. Bi W, Wang F, Bi Y, Wang T, Xue P, Zhang Y, Gao X, Liu S, Wang Z, Li M, Baudy-Floc'h M, Robinson SC, Ngerebara N, Bi L. Eur J Pharmacol. 2009 Aug 15;616(1-3):256-64.
Protective effect of nitronyl nitroxide-amino acid conjugates on liver ischemiareperfusion induced injury in rats. Bi W, Cai J, Xue P, Zhang Y, Liu S, Gao X, Li M, Wang Z, Baudy-Floc'h M, Green SA, Bi L. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1788-94.
Toward the development of chemoprevention agents (III): synthesis and antiinflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3- dioxacycloalkanes. Bi L, Zhao M, Gu K, Wang C, Ju J, Peng S. Bioorg Med Chem. 2008 Feb 15;16(4):1764-74.
3'-O-modified nucleotides as reversible terminators for pyrosequencing. Wu J, Zhang S, Meng Q, Cao H, Li Z, Li X, Shi S, Kim DH, Bi L, Turro NJ, Ju J. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16462-7.
Design, synthesis and cardioprotective effect of a new class of dual-acting agents: phenolic tetrahydro-beta-carboline RGD peptidomimetic conjugates. Bi W, Cai J, Liu S, Baudy-Floc'h M, Bi L. Bioorg Med Chem. 2007 Nov 15;15(22):6909-19.
Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl- 1,3-dioxacycloalkanes. Gu K, Bi L, Zhao M, Wang C, Ju J, Peng S. Bioorg Med Chem. 2007 Sep 15;15(18):6273-90.
Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes. Gu K, Bi L, Zhao M, Wang C, Ju J, Peng S. Bioorg Med Chem. 2007 Jul 15;15(14):4775-99.
Design and synthesis of pentahydroxylhexylamino acids and their effect on lead decorporation. Wang Y, Bi L, Hou B, Chen Y, Zhao M, Wang C, Wang W, Ju J, Peng S. Chem Res Toxicol. 2007 Apr;20(4):609-15.
Heteroclitic properties of mixed alpha- and aza-beta3-peptides mimicking a supradominant CD4 T cell epitope presented by nucleosome. Dali H, Busnel O, Hoebeke J, Bi L, Decker P, Briand JP, Baudy-Floc'h M, Muller S. Mol Immunol. 2007 Apr;44(11):3024-36.
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators. Ju J, Kim DH, Bi L, Meng Q, Bai X, Li Z, Li X, Marma MS, Shi S, Wu J, Edwards JR, Romu A, Turro NJ. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19635-40.
Synthesis and cytotoxic activities of beta-carboline amino acid ester conjugates. Zhao M, Bi L, Wang W, Wang C, Baudy-Floc'h M, Ju J, Peng S. Bioorg Med Chem. 2006 Oct 15;14(20):6998-7010.
Dual-acting agents that possess free radical scavenging and antithrombotic activities: design, synthesis, and evaluation of phenolic tetrahydro-beta-carboline RGD peptide conjugates. Bi W, Bi L, Cai J, Liu S, Peng S, Fischer NO, Tok JB, Wang G. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4523-7.
Novel 2-substituted nitronyl nitroxides as free radical scavengers: synthesis, biological evaluation and structure-activity relationship. Wu Y, Bi L, Bi W, Li Z, Zhao M, Wang C, Ju J, Peng S. Bioorg Med Chem. 2006 Aug 15;14(16):5711-20. 21. Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity. Zhao M, Bi L, Bi W, Wang C, Yang Z, Ju J, Peng S. Bioorg Med Chem. 2006 Jul 15;14(14):4761-74.
Design and synthesis of a photocleavable fluorescent nucleotide 3'-O-allyl-dGTPPC- Bodipy-FL-510 as a reversible terminator for DNA sequencing by synthesis. Meng Q, Kim DH, Bai X, Bi L, Turro NJ, Ju J. J Org Chem. 2006 Apr 14;71(8):3248-52.
Design and synthesis of a chemically cleavable fluorescent nucleotide, 3'-O-allyldGTP- allyl-bodipy-FL-510, as a reversible terminator for DNA sequencing by synthesis. Bi L, Kim DH, Ju J. J Am Chem Soc. 2006 Mar 1;128(8):2542-3.
Solid-phase synthesis of "mixed" peptidomimetics using Fmoc-protected aza-beta3- amino acids and alpha-amino acids. Busnel O, Bi L, Dali H, Cheguillaume A, Chevance S, Bondon A, Muller S, Baudy-Floc'h M. J Org Chem. 2005 Dec 23;70(26):10701-8.
Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes. Gu K, Bi L, Zhao M, Wang C, Dolan C, Kao MC, Tok JB, Peng S. Bioorg Med Chem. 2006 Mar 1;14(5):1339-47.
Novel synthesis and anti-inflammatory activities of 2,5-disubstituteddioxacycloalkanes. Bi L, Zhang Y, Zhao M, Wang C, Chan P, Tok JB, Peng S. Bioorg Med Chem. 2005 Oct 1;13(19):5640-6.
Design and synthesis of a 3'-O-allyl photocleavable fluorescent nucleotide as a reversible terminator for DNA sequencing by synthesis. Ruparel H, Bi L, Li Z, Bai X, Kim DH, Turro NJ, Ju J. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5932-7.
Specific recognition of naphthyridine-based ligands toward guanine-containing bulges in RNA duplexes and RNA-DNA heteroduplexes. Tok JB, Bi L, Saenz M. Bioorg Med Chem Lett. 2005 Feb 1;15(3):827-31.
A comparative binding study of BIV Tat peptide against its TAR RNA duplex, RNADNA heteroduplex and DNA duplex. Tok JB, Bi L. Bioorg Med Chem Lett. 2005 Jan 3;15(1):129-33.
A comparative binding study of modified bovine immunodeficiency virus TAR RNA against its TAT peptide. Tok JB, Bi L, Huang S. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6101-5.
Aminoglycoside and its derivatives as ligands to target the ribosome. Tok JB, Bi L. Curr Top Med Chem. 2003;3(9):1001-19.
Diastereoselective cyclizations with enantiopure malonaldehyde monocycloacetals. Bi L, Zhao M, Wang C, Peng S, Winterfeldt E. J Org Chem. 2002 Jan 11;67(1):22-6.

Patents

Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators. PCT Int. Appl. (2008), 96pp. WO 2008069973
SBS (DNA sequencing by synthesis) using chemically cleavable 3'-O-allyl-dNTP-allyl-fluorophore fluorescent nucleotide analogues. PCT Int. Appl. (2007), 52pp. WO 2007053719
Synthesis of four-color 3'-O-allyl modified photocleavable fluorescent nucleotides and their incorporation into DNA using polymerase. PCT Int. Appl. (2007), 112pp. WO 2007053702
Preparation of 1,3-Dioxane Derivatives Having Protein Kinase C Inhibitory Activity and their Therapeutic Use. US Pub.App.20050043396
1,3-dioxane derivatives, its preparation and their therapeutic use. CN Pub. App 1450064