Chemical biology: development of novel molecular probes for DNA sequencing analysis
and disease gene discovery
Medicinal chemistry: development of new imaging and therapeutic agents towards cancer
and cardiovascular disease; Design and synthesis of novel prodrugs of peptides and
peptide mimetics.
Recent Publications
Novel TEMPO-PEG-RGDs Conjugates Remediate Tissue Damage Induced by Acute Limb Ischemia/Reperfusion.
Bi W, Li X, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Itagaki Y, Bi L. J. Med. Chem.
2012 May 10;55(9):4501-5.
Determination of intracellular pH using sensitive, clickable fluorescent probes. Yapici
NB, Mandalapu SR, Chew TL, Khuon S, Bi L. Bioorg Med Chem Lett. 2012 Apr 1; 22(7):2440-3.
New rhodamine nitroxide based fluorescent probes for intracellular hydroxyl radical
identification in living cells. Yapici NB, Jockusch S, Moscatelli A, Mandalapu SR,
Itagaki Y, Bates DK, Wiseman S, Gibson KM, Turro NJ, Bi L. Org Lett. 2012 Jan 6;14(1):50-3.
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion
injury in the rat. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M,
Ngerebara N, Li X, Gibson KM, Bi L. Eur J Med Chem. 2011 Jun;46(6):2441-52.
A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in
acute limb ischemia/reperfusion injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z,
Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM, Bi L. Eur J. Med Chem. 2011 May;46(5):1453-62.
Synthetic oligodeoxynucleotide purification by polymerization of failure sequences.
Fang S, Fueangfung S, Lin X, Zhang X, Mai W, Bi L, Green SA. Chem Commun (Camb). 2011
Jan 28;47(4):1345-7.
Synthesis and characterization of novel indole derivatives reveal improved therapeutic
agents for treatment of ischemia/reperfusion (I/R) injury. Bi W, Bi Y, Xue P, Zhang
Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM, Bi L. J. Med Chem.
2010 Sep 23;53(18):6763-7.
Patents
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible
terminators. PCT Int. Appl. (2008), 96pp. WO 2008069973
SBS (DNA sequencing by synthesis) using chemically cleavable 3'-O-allyl-dNTP-allyl-fluorophore
fluorescent nucleotide analogues. PCT Int. Appl. (2007), 52pp. WO 2007053719
Synthesis of four-color 3'-O-allyl modified photocleavable fluorescent nucleotides
and their incorporation into DNA using polymerase. PCT Int. Appl. (2007), 112pp. WO
2007053702
Preparation of 1,3-Dioxane Derivatives Having Protein Kinase C Inhibitory Activity
and their Therapeutic Use. US Pub.App.20050043396
1,3-dioxane derivatives, its preparation and their therapeutic use. CN Pub. App 1450064
