Cardiovascular physiology, neurophysiology and exercise science.
Neural mechanisms of cardiovascular diseases and metabolic disorders.
Neural mechanisms of exercise training in regulating autonomic and cardiovascular function.
Andrew D. Chapp, Zixi Cheng, Zhiying Shan, Qing-Hui Chen. Long-term high salt intake involves reduced small conductance Ca2+-activated K+ (SK) current and increased excitability of PVN neurons with projections to the rostral ventrolateral medulla in rats. Neural Plasticity 2017 Sep. (Accepted)
Fan Y, Jiang E, Hahka T, Chen QH*, Yan J*, Shan Z*. Orexin A increases sympathetic nerve activity through promoting expression of proinflammatory cytokines in Sprague-Dawley rats. Acta Physiologica 2017 Aug. 30 [Epub ahead of print]
Huber MJ, Fan Y, Jiang E, Zhu F, Larson RA, Yan J, Li N, Chen QH, Shan Z. Increased Activity of the Orexin System in the Paraventricular Nucleus Contributes to Salt Sensitive Hypertension. Am J Physiology Heart Circulation Physiology 2017 Jun 30 [Epub ahead of print]
Huber MJ, Chen QH, Shan Z. The Orexin System and Hypertension. Cellular and molecular neurobiology. 2017 Mar 27 [Epub ahead of print]
Larson RA, Chapp AD, Gui L, Huber MJ, Cheng ZJ, Shan Z, Chen QH. High Salt Intake Augments Excitability of PVN Neurons in Rats: Role of the Endoplasmic Reticulum Ca2+ Store. Frontiers in neuroscience. 2017; 11:182 (p1-12).
Chen J, Li Z, Hatcher JT, Chen QH, Chen L, Wurster RD, Chan SL, Cheng Z. Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation. Frontiers in neuroscience. 2017; 11:138 (p1-13).
Ji Y, Guo X, Zhang Z, Huang Z, Zhu J, Chen QH, Gui L. CaMKIIδ Meditates Phenylephrine Induced Cardiomyocyte Hypertrophy Through Store-Operated Ca 2+ Entry. Cardiovascular Pathology 2017 27:9-17
Huber MJ, Basu R, Cecchettini C, Cuadra AE, Chen QH, Shan Z. Activation of the (pro)renin receptor in the paraventricular nucleus increases sympathetic outflow in anesthetized rats. Am J Physiology Heart Circulation Physiology 2015; 309(5):H880-887
Larson RA*, Le Gui*, Huber MJ, Chapp AD, Zhu J, LaGrange LP, Shan Z, Chen QH. Sympathoexcitation in AngII-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus. Am J Physiology Heart Circulation Physiology 2015; 308(12):H1547-555. (* equal contribution)
Chapp AD*, Gui L*, Huber MJ, Larson RA, Gu M, Zhu J, Carter JR and Chen QH. Sympathoexcitation and pressor responses induced by ethanol in the central nucleus of amygdale (CeA) involves local activation of NMDA receptors in anesthetized rats. Am J Physiol Heart Circulation Physiology 2014; 307(5):H701-709. (* equal contribution)
Bardgett ME, Chen QH, Guo Q, Calderon AS, Andrade MA, Toney GM. Coping with Dehydration: Sympathetic Activation and Regulation of Glutamatergic Transmission in the Hypothalamic PVN. Am J Physiol Regul Integr Comp Physiol. 2014; 306(11):R804-813.
Lin M, Hatcher JT, Wurster RD, Chen QH, Cheng ZJ. Characteristics of Single Large-Conductance Ca2+-Activated K+ Channels and Their Regulation of Action Potentials and Excitability in vagal Cardiac Motoneurons. Am J Physiol Cell Physiol. 2014; 306(2):C152-166.
Gui L, Bao Z, Jia Y, Qin X, Cheng ZX, Zhu J, Chen QH. Ventricular tachyarrhythmias in rats with acute myocardial infarction involves activation of small-conductance Ca2+-activated K+-channels. Am J Physiol Heart and Circ Physiol. 2013; 304(1):H118-130.
More publications are available in Download CV.
National Institutes Health (NIH) 1R15HL122952 “ER Stress and Reduced SK Channel Function in PVN in Rats with High Salt Intake”
AHA 16PRE27780121 “Acetate as an Active Metabolite of Ethanol: Neural and Cardiovascular Implications”
NIH 1R15HL129213-01 “Prorenin receptor and sympathetic activation in salt-sensitive hypertension”
AHA (SDG, National Center)
Michigan Technological University Research Excellence Fund (REF)
Qing-Hui Chen. “Integrative Physiology-- -Exercise and Autonomic Control of Cardiovascular Function”. Oral Presentation. Invited featured faculty talk in China Heart Congress (2017CHC) Sponsored by Chinese Medical Association and National Center for Cardiovascular Diseases. (China National Conversion Center, Peking, China. Aug. 10-13, 2017)
Andrew D. Chapp, Kyle M. Driscoll, Jessica Behnke, Zhiying Shan, Qing-Hui Chen. Acetate, an Ethanol Metabolite Increases Neuroinflammation and Neuronal Death: Implications in Ethanol Neurodegeneration. Experiment Biology 2017 (Chicago, USA. April 22-26, 2017). (A. D. Chapp and Jessica Behnke are graduate students in my Lab at MTU)
Jessica E. Behnke, Andrew D. Chapp, Kyle M. Driscoll, Zhiying Shan, Qing-Hui Chen. Acetate, the Metabolite of Ethanol, Increases Cytosolic Calcium and mRNA Expression Levels of EGR1 and TNFα in Dopaminergic Like PC12 Cells. Experiment Biology 2017 (Chicago, USA. April 22-26, 2017). (A. D. Chapp andJessica Behnke are graduate students in my Lab at MTU)
Zixi Cheng, Ming Lin, Glenn M. Toney, Qing-Hui Chen. Small-conductance Ca2+-activated K+ (SK) channels regulate pre-sympathetic neurons in the hypothalamic paraventricular nucleus (PVN) and parasympathetic cardiomotor neurons (CMN) in the nucleus ambiguus (NA): Pathological changes. Selected oral presentation for FT sponsored by APS-NCAR section. Experiment Biology 2017 (Chicago, USA. April 22-26, 2017).
Enshe Jiang, Michael Huber, Yuanyuan Fan, Fengli Zhu, Qing-Hui Chen, Zhiying Shan. High salt intake induces sympathetic activation in Dahl salt-sensitive rats through activation of orexin-TNF signaling in the hypothalamic paraventricular nucleus (PVN). Experiment Biology 2017 (Chicago, USA. April 22-26, 2017).
Andrew D. Chapp, K.M. Driscoll, M.J. Huber, Z. Shan, J.R. Carter. L. Zhang, Q.H. Chen. The Excitatory and Cytotoxic Actions of Acetate on Neurons. Research Society on Alcoholism 2017 (Denver, CO, June 24-28, 2017) (A. D. Chapp and M.J. Huber are graduate students in my Lab at MTU)
Andrew D. Chapp, K. Driscoll, J. Behnke, Z. Shan, L. Zhang, QH. Chen. Acidification with Acetic Acid Activates NMDAR and Increases Central Nucleus of Amygdala Neurons with Axon Projecting to Rostral Ventrolateral Medulla. Research Society on Alcoholism 2017 (Denver, CO, Denver, CO, June 24-28, 2017)(A. D. Chapp and Jessica Behnke are graduate students in my Lab at MTU).
Robert A. Larson, Andrew D. Chapp, Michael J. Huber, Zixi Cheng, Zhiying Shan, Qing-Hui Chen. High salt intake augments excitability of pre-sympathetic PVN neurons through dysfunction of the endoplasmic reticulum Ca2+ ATPase. 2015 HBPR Scientific Sessions (Washington, DC, USA. Sep. 16-29, 2015).
Michael J. Huber, Rupsa Basu, Qing-Hui Chen and Zhiying Shan. Prorenin Receptor Activation in the PVN Increases Sympathetic Outflow in Anesthetized Rat. Experiment Biology 2015 (Boston, USA. March 28-April 01, 2015).
Michael J Huber, Andrew D Chapp, Le Gui, Mingjun Gu, Zhiying Shan, Qing-Hui Chen. Sympathoexcitation by inhibition of SK channel activity in the hypothalamic PVN is attenuated by local AT1 receptor blockade. Experiment Biology 2015 (Boston, USA. March 28-April 01, 2015).
Andrew D Chapp, Michael J Huber, Jason R Carter, Qing-Hui Chen. Acetate is an active metabolite of ethanol: increases firing and evokes inward currents through activation of NMDA receptors in RVLM projecting CeA neurons. Experiment Biology 2015 (Boston, USA. March 28-April 01, 2015).
A.D. Chapp; R. A. Larson; M.J. Huber; M.J. Gu; J.R. Carter; Q.H. Chen. Acetate increases firing and evokes inward currents through activation of NMDA receptors in RVLM projecting CeA neurons. Alcoholism – Clinical and Experimental Research. 38:163A, 2014. The 37th Annual Research Society on Alcoholism Scientific Meeting (Belleve, Washington, June 21-25, 2014).
Stream SF, Durocher JJ, Chen QH, and Carter JR. Acute alcohol consumption elicits augmented sympathoexcitation in prehypertensive humans. Alcoholism – Clinical and Experimental Research. 38:163A, 2014. The 37th Annual Research Society on Alcoholism Scientific Meeting (Belleve, Washington, June 21-25, 2014).