Cardiovascular physiology, neurophysiology and exercise science.
Neural mechanisms of cardiovascular diseases and metabolic disorders.
Neural mechanisms of exercise training in regulating autonomic and cardiovascular
Andrew D. Chapp, Zixi Cheng, Zhiying Shan, Qing-Hui Chen. Long-term high salt intake
involves reduced small conductance Ca2+-activated K+ (SK) current and increased excitability
of PVN neurons with projections to the rostral ventrolateral medulla in rats. Neural
Plasticity 2017 Sep. (Accepted)
Fan Y, Jiang E, Hahka T, Chen QH*, Yan J*, Shan Z*. Orexin A increases sympathetic
nerve activity through promoting expression of proinflammatory cytokines in Sprague-Dawley
rats. Acta Physiologica 2017 Aug. 30 [Epub ahead of print]
Huber MJ, Fan Y, Jiang E, Zhu F, Larson RA, Yan J, Li N, Chen QH, Shan Z. Increased
Activity of the Orexin System in the Paraventricular Nucleus Contributes to Salt Sensitive
Hypertension. Am J Physiology Heart Circulation Physiology 2017 Jun 30 [Epub ahead
Huber MJ, Chen QH, Shan Z. The Orexin System and Hypertension. Cellular and molecular
neurobiology. 2017 Mar 27 [Epub ahead of print]
Larson RA, Chapp AD, Gui L, Huber MJ, Cheng ZJ, Shan Z, Chen QH. High Salt Intake
Augments Excitability of PVN Neurons in Rats: Role of the Endoplasmic Reticulum Ca2+
Store. Frontiers in neuroscience. 2017; 11:182 (p1-12).
Chen J, Li Z, Hatcher JT, Chen QH, Chen L, Wurster RD, Chan SL, Cheng Z. Deletion
of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity
Following Cerebral Ischemia and Oxygen-Glucose Deprivation. Frontiers in neuroscience.
2017; 11:138 (p1-13).
Ji Y, Guo X, Zhang Z, Huang Z, Zhu J, Chen QH, Gui L. CaMKIIδ Meditates Phenylephrine
Induced Cardiomyocyte Hypertrophy Through Store-Operated Ca 2+ Entry. Cardiovascular
Pathology 2017 27:9-17
Huber MJ, Basu R, Cecchettini C, Cuadra AE, Chen QH, Shan Z. Activation of the (pro)renin
receptor in the paraventricular nucleus increases sympathetic outflow in anesthetized
rats. Am J Physiology Heart Circulation Physiology 2015; 309(5):H880-887
Larson RA*, Le Gui*, Huber MJ, Chapp AD, Zhu J, LaGrange LP, Shan Z, Chen QH. Sympathoexcitation
in AngII-salt hypertension involves reduced SK channel function in the hypothalamic
paraventricular nucleus. Am J Physiology Heart Circulation Physiology 2015; 308(12):H1547-555.
(* equal contribution)
Chapp AD*, Gui L*, Huber MJ, Larson RA, Gu M, Zhu J, Carter JR and Chen QH. Sympathoexcitation
and pressor responses induced by ethanol in the central nucleus of amygdale (CeA)
involves local activation of NMDA receptors in anesthetized rats. Am J Physiol Heart
Circulation Physiology 2014; 307(5):H701-709. (* equal contribution)
Bardgett ME, Chen QH, Guo Q, Calderon AS, Andrade MA, Toney GM. Coping with Dehydration:
Sympathetic Activation and Regulation of Glutamatergic Transmission in the Hypothalamic
PVN. Am J Physiol Regul Integr Comp Physiol. 2014; 306(11):R804-813.
Lin M, Hatcher JT, Wurster RD, Chen QH, Cheng ZJ. Characteristics of Single Large-Conductance
Ca2+-Activated K+ Channels and Their Regulation of Action Potentials and Excitability
in vagal Cardiac Motoneurons. Am J Physiol Cell Physiol. 2014; 306(2):C152-166.
Gui L, Bao Z, Jia Y, Qin X, Cheng ZX, Zhu J, Chen QH. Ventricular tachyarrhythmias
in rats with acute myocardial infarction involves activation of small-conductance
Ca2+-activated K+-channels. Am J Physiol Heart and Circ Physiol. 2013; 304(1):H118-130.
More publications are available in Download CV.
National Institutes Health (NIH) 1R15HL122952 “ER Stress and Reduced SK Channel Function
in PVN in Rats with High Salt Intake”
AHA 16PRE27780121 “Acetate as an Active Metabolite of Ethanol: Neural and Cardiovascular
NIH 1R15HL129213-01 “Prorenin receptor and sympathetic activation in salt-sensitive
AHA (SDG, National Center)
Michigan Technological University Research Excellence Fund (REF)
Qing-Hui Chen. “Integrative Physiology-- -Exercise and Autonomic Control of Cardiovascular
Function”. Oral Presentation. Invited featured faculty talk in China Heart Congress
(2017CHC) Sponsored by Chinese Medical Association and National Center for Cardiovascular
Diseases. (China National Conversion Center, Peking, China. Aug. 10-13, 2017)
Andrew D. Chapp, Kyle M. Driscoll, Jessica Behnke, Zhiying Shan, Qing-Hui Chen. Acetate,
an Ethanol Metabolite Increases Neuroinflammation and Neuronal Death: Implications
in Ethanol Neurodegeneration. Experiment Biology 2017 (Chicago, USA. April 22-26,
2017). (A. D. Chapp and Jessica Behnke are graduate students in my Lab at MTU)
Jessica E. Behnke, Andrew D. Chapp, Kyle M. Driscoll, Zhiying Shan, Qing-Hui Chen.
Acetate, the Metabolite of Ethanol, Increases Cytosolic Calcium and mRNA Expression
Levels of EGR1 and TNFα in Dopaminergic Like PC12 Cells. Experiment Biology 2017 (Chicago,
USA. April 22-26, 2017). (A. D. Chapp andJessica Behnke are graduate students in my
Lab at MTU)
Zixi Cheng, Ming Lin, Glenn M. Toney, Qing-Hui Chen. Small-conductance Ca2+-activated
K+ (SK) channels regulate pre-sympathetic neurons in the hypothalamic paraventricular
nucleus (PVN) and parasympathetic cardiomotor neurons (CMN) in the nucleus ambiguus
(NA): Pathological changes. Selected oral presentation for FT sponsored by APS-NCAR
section. Experiment Biology 2017 (Chicago, USA. April 22-26, 2017).
Enshe Jiang, Michael Huber, Yuanyuan Fan, Fengli Zhu, Qing-Hui Chen, Zhiying Shan.
High salt intake induces sympathetic activation in Dahl salt-sensitive rats through
activation of orexin-TNF signaling in the hypothalamic paraventricular nucleus (PVN).
Experiment Biology 2017 (Chicago, USA. April 22-26, 2017).
Andrew D. Chapp, K.M. Driscoll, M.J. Huber, Z. Shan, J.R. Carter. L. Zhang, Q.H. Chen.
The Excitatory and Cytotoxic Actions of Acetate on Neurons. Research Society on Alcoholism
2017 (Denver, CO, June 24-28, 2017) (A. D. Chapp and M.J. Huber are graduate students
in my Lab at MTU)
Andrew D. Chapp, K. Driscoll, J. Behnke, Z. Shan, L. Zhang, QH. Chen. Acidification
with Acetic Acid Activates NMDAR and Increases Central Nucleus of Amygdala Neurons
with Axon Projecting to Rostral Ventrolateral Medulla. Research Society on Alcoholism
2017 (Denver, CO, Denver, CO, June 24-28, 2017)(A. D. Chapp and Jessica Behnke are
graduate students in my Lab at MTU).
Robert A. Larson, Andrew D. Chapp, Michael J. Huber, Zixi Cheng, Zhiying Shan, Qing-Hui
Chen. High salt intake augments excitability of pre-sympathetic PVN neurons through
dysfunction of the endoplasmic reticulum Ca2+ ATPase. 2015 HBPR Scientific Sessions
(Washington, DC, USA. Sep. 16-29, 2015).
Michael J. Huber, Rupsa Basu, Qing-Hui Chen and Zhiying Shan. Prorenin Receptor Activation
in the PVN Increases Sympathetic Outflow in Anesthetized Rat. Experiment Biology 2015
(Boston, USA. March 28-April 01, 2015).
Michael J Huber, Andrew D Chapp, Le Gui, Mingjun Gu, Zhiying Shan, Qing-Hui Chen.
Sympathoexcitation by inhibition of SK channel activity in the hypothalamic PVN is
attenuated by local AT1 receptor blockade. Experiment Biology 2015 (Boston, USA. March
28-April 01, 2015).
Andrew D Chapp, Michael J Huber, Jason R Carter, Qing-Hui Chen. Acetate is an active
metabolite of ethanol: increases firing and evokes inward currents through activation
of NMDA receptors in RVLM projecting CeA neurons. Experiment Biology 2015 (Boston,
USA. March 28-April 01, 2015).
A.D. Chapp; R. A. Larson; M.J. Huber; M.J. Gu; J.R. Carter; Q.H. Chen. Acetate increases
firing and evokes inward currents through activation of NMDA receptors in RVLM projecting
CeA neurons. Alcoholism – Clinical and Experimental Research. 38:163A, 2014. The 37th
Annual Research Society on Alcoholism Scientific Meeting (Belleve, Washington, June
Stream SF, Durocher JJ, Chen QH, and Carter JR. Acute alcohol consumption elicits
augmented sympathoexcitation in prehypertensive humans. Alcoholism – Clinical and
Experimental Research. 38:163A, 2014. The 37th Annual Research Society on Alcoholism
Scientific Meeting (Belleve, Washington, June 21-25, 2014).