Chandrashekhar P. Joshi
Department Chair and Professor, Biological Sciences
- PhD, Biochemistry, University of Poona, India
- MS, Botany, University of Poona, India
- BS, Botany, University of Poona, India
Unraveling the mechanism of cellulose biosynthesis in trees
I am a plant molecular biologist who is interested in understanding of how trees make cellulose. Simply put, cellulose is a chain of glucose molecules, and a large number of such cellulose chains weave together with other polymers to form plant cell walls. Cellulose biosynthesis is also one of the most ancient and essential life processes of plants.
Due to its omnipresence in terrestrial ecosystems, we use a large number of cellulose products in our day-to-day life in the form of paper, furniture, clothes, medicines and even food. Ironically, we knew little about how plants synthesize cellulose until recently. However, the last decade has witnessed remarkable progress in understanding the molecular mechanisms of cellulose biosynthesis using Arabidopsis, a small herb that has been a sweetheart to many plant scientists. I am attempting to understand whether majestic trees such as poplars and pines that make copious amounts of wood cellulose every year do this feat by using a similar mechanism. To that effect, we have cloned a large number of cellulose synthases and other related genes from poplars and are applying functional genomics approaches to clarify their roles in wood formation.
I love to teach classes in molecular genetics, genomics and bioinformatics. When I clarify a difficult concept, it is always rewarding to see a twinkle of understanding in my student's eyes. I firmly believe that what I am today is because of my teachers, who took time to patiently explain the basic scientific concepts to me. You can learn almost anything if you understand the basics. I also teach a course on how to write successful grant proposals. So far, about 70 graduate students from a variety of disciplines have taken my course and some have even obtained funding for their own research. I always have open research positions for undergraduates and graduates to work in my lab, so feel free to drop me a line or call me. My doors are always open to curious minds!
Links of Interest
- Life Science and Technology Institute
- Ecosystem Science Center
- Chonnam National University
- Transatlantic Master's Degree in Forest Resources
Research Interests, Biological Sciences
- Plant Molecular Genetics
Areas of Expertise, Biology and Forestry
- Cellulose and lignin biosynthesis in trees
- Wood formation
- Tree growth and development
- Engineering trees
- Forest bioinformatics
- Shashank K. Pandey, Nookaraju Akula, Takeshi Fujino, Sivakumar Pattathil, and Chandrashekhar P. Joshi* (2016) Virus Induced Gene Silencing (VIGS) Mediated Functional Characterization of Two Genes Involved in Lignocellulosic Secondary Cell Wall Formation. Plant Cell Reports, 35:2353-2367.
- Puranik Swati, Kavitha S. Kumar, Oliver Gailing and Chandrashekhar P. Joshi* (2014) Modifying plant cell walls for bioenergy production. CAB Reviews 9, 017, pp 1-10.
- Nookaraju Akula, Shashank K. Pandey, Takeshi Fujino, Ju Young Kim, Mi Chung Suh, and Chandrashekhar P. Joshi* (2014) Enhanced Accumulation of Fatty Acids and Triacylglycerols in Transgenic Tobacco Stems for Enhanced Bioenergy Production. Plant Cell Reports 33 (7) 1041-1052.
- Sera Jung, Dae-Seok Lee, Yeon-Ok Kim, Chandrashekhar P. Joshi, and Hyeun-Jong Bae (2013) Improved recombinant cellulase expression in chloroplast of tobacco through promoter engineering and 5′ amplification promoting sequence. Plant Molecular Biology 83: 317–328. Published online in June 2013. DOI 10.1007/s11103-013-0088-2.
- Nookaraju A, Pandey SP, Bae HJ and Joshi CP* (2013) Designing cell walls for better bioenergy production. Molecular Plant 6 (1):8-10. doi: 10.1093/mp/sss111 First published online: October 5, 2012.
- Liu Y, Xu F, Gou J, Al-Haddad J, Telewski FW, Bae HJ and C. P. Joshi* (2012) Importance of Two Consecutive Methionines at the N-terminus of a Cellulose Synthase (PtdCesA8) for Normal Wood Cellulose Synthesis in Transgenic Aspen. Tree Physiology 32(11): 1403-1412 first published online October 17, 2012
- Chandrashekhar P. Joshi*, Shivegowda Thammannagowda, Takeshi Fujino, Jiqing Gou, Utku Avci, Candace H. Haigler, Lisa M. McDonnell, Shawn D. Mansfield, Bemnet Menghesa, Nicholas C. Carpita, Darby Harris, Seth DeBolt and Gary F. Peter (2011) Perturbation of wood cellulose synthesis causes pleiotropic effects in transgenic aspen. Molecular Plant 4(2) 331-345.
- Zhu X, Pattahil S, Mazumdar K, Brehm A, Hahn MG. Dinesh-Kumar SP and C. P. Joshi* (2010) Virus-induced gene silencing offers a functional genomics platform for studying plant cell wall formation. Molecular Plant 3 (5): 818-833.